Abstract: Microbiology open experimental course is an important part of deepening the content of classroom-teaching in colleges. Combining the actual situation of microbiology open experimental teaching work in school of life science and according to the progress of frontier science, this paper explored the reform of microbiology open experimental course by setting an “integrated” experimental course. This reform aimed to stimulate the divergent thinking of students and cultivate the students to be the applied creative talents, which reserved talents for science and technology progress and application practices.

Key words: microbiology, open experimental course, frontier science, innovative thinking